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EBM Resources

Sources of Evidence

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Recommended Sources of Evidence (at each level of the pyramid)

Systems: the technologies are still new and being refined.  They rely on new advances in computer science.

  • Integrated Electronic Health Records
  • IBM Micromedex Watson
  • UpToDate Clinical Pathways
  • VisualDx Differential Diagnosis

Summaries and Guidelines: integrate the body of evidence on a topic and aim to provide recommendations for optimal management

  • Professional Society Guidelines (on their websites or published in their flagship journals)
  • ECRI Trust
  • UpToDate
  • DynaMed
  • ClinicalKey

Synopses: succinct descriptions of an individual study or systematic review often found in specialized (secondary evidence) journals.

  • ACP Journal Club (found in the Annals of Internal Medicine)
  • DARE (Database of Abstracts of Reviews and Effects) accessible via Cochrane Library
  • Specialized secondary evidence journals

Syntheses: comprehensive summaries of research related to a focused clinical question. Include systematic reviews and meta-anlyses.

  • Cochrane Library
  • Epistimonikos
  • PubMed Clinical Queries
  • Bibliographic databases such as PubMed, MEDLINE, Embase, CINAHL, TRIP, and ACCESSSS that have study/publication type filters for systematic reviews and meta-anlyses
  • Federated search engines that source results from publishers and database containing articles with systematic reviews and meta-anylses

Studies: sources of original studies

  • PubMed (includes MEDLINE)
  • Embase
  • CINAHL
  • ClinicalKey
  • Cochrane Central Register of Controlled Trials
  • ClinicalTrials.gov
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